Enzymatica signs agreement with Qualia Pharma for Greece and Cyprus

News   •   May 22, 2018 06:30 GMT

Enzymatica has entered into a distribution agreement with Qualia Pharma for marketing and sales of ColdZyme® Mouth Spray on the Greek and Cypriot market. The background to the agreement is that Qualia Pharma acquired Life NLB on March 1, 2018. The distribution agreement that Enzymatica previously had with Life NLB is now being transferred to Qualia Pharma.

“We see a clear advantage to signing an agreement with Qualia Pharma, which is a larger market participant and can conduct a stronger marketing campaign for ColdZyme in Greece and on Cyprus,” says Fredrik Lindberg, CEO of Enzymatica.

“We see excellent potential for ColdZyme in our market, given the successful launch in other European markets. We consider being able to sell a product that attacks the cause of colds – viruses – to be a major advantage compared with most cold products, which are aimed at alleviating symptoms,” says Fotis Sakellaridis, CEO of Qualia Pharma.

The Greek and Cypriot cold products market, which is estimated to be worth SEK 670 million, is a stable market. ColdZyme began to be sold to pharmacies in both markets in 2017. In 2018 a launch was initiated targeting consumers, pharmacists and healthcare personnel.

Qualia Pharma is a Greek pharmaceutical company active in pharmaceuticals, nutritional supplements and medical devices. The company was founded in 2009 and conducts research in fields such as osteoarthritis, diseases of the central nervous system (CNS) such as Alzheimer’s and Parkinson’s, and biological products for development of drug molecules. Qualia Pharma conducts research in collaboration with universities and research institutes. The company has 43 employees and sales of SEK 50 million.

For more information, please contact:

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a Swedish life science company that develops and sells medical devices for infection-related diseases. The products are based on a barrier technology that includes marine enzymes. The company’s first product is ColdZyme® Mouth Spray, which can prevent colds and reduce the duration of disease. The product has been launched in about ten markets. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company has its headquarters in Lund and is listed on Nasdaq First North. For more information, visit:www.enzymatica.com.

Enzymatica’s certified adviser is Erik Penser Bank.

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New results from Enzymatica’s in vitro study: ColdZyme also deactivates corona virus

Press Releases   •   Apr 11, 2018 06:45 GMT

Today Enzymatica announced the results of an in vitro study demonstrating the ability of ColdZyme® Mouth Spray to deactivate human corona virus – one of the most common cold virus families. Along with the in vitro results from a study published in the autumn of 20171, ColdZyme has been shown to be able to deactivate over 90 % of the known viruses that cause colds.

The current results, which are being presented today at Ear-Nose-and-Throat days in Linköping2, show that ColdZyme deactivates human corona virus and reduces the cytopathic (cell damaging) effect by 99.9 % in vitro. The corona virus is potentially dangerous because in addition to the common cold, it also causes diseases such as SARS (Severe acute respiratory syndrome), and MERS (Middle East respiratory syndrome),which is a contagious pneumonia.

“Even if the current in vitro results cannot be directly translated into clinical efficacy, it is very interesting that ColdZyme is able to effectively deactivate the absolute majority of our most common cold viruses. These results help us to better understand ColdZyme’s preventive effect and its ability to reduce the duration of colds,” says Fredrik Lindberg, CEO of Enzymatica.

The results regarding the corona virus complement previously published in vitro data, which showed that ColdZyme also deactivates four other common virus families that cause colds. Thus ColdZyme has been shown to be 91.7 % effective in deactivating rhinovirus type 1A , 92.8 % effective for rhinovirus type 42, 96.9 % for human influenza A virus H3N2, 99.9 % for RSV virus, 64.5 % effective for adenovirus type 2 and 99.9 % effective for human corona virus, without any cell-damaging effect. In summary, ColdZyme has been shown to be effective against more than 90 % of our most common cold viruses. All in vitro experiments were carried out by an independent, accredited and certified laboratory.

The in vitro study was based on standardized and validated methods developed to resemble the in vivo environment in the mouth and throat, where viruses attach, invade the cells and cause colds. ColdZyme, which consists of glycerol and trypsin, an enzyme found in Arctic cod, forms a barrier in the throat against the cold virus. ColdZyme’s effect is believed to be due in part to the ability of trypsin to cleave proteins on the surface of the virus particles that are important for their ability to infect cells. This can prevent colds because the virus particles are unable to bind to receptors on the surface of the cells.

  1. Stefansson B, Gudmundsdottir A, Clarsund M (2017) A medical device forming a protective barrier that deactivates four major common cold viruses.Virol Res Rev 1: DOI: 10.15761/VRR.1000130
  2. Stefansson et al, ColdZyme forms a protective barrier in the throat that deactivates five major common cold viruses, Congress of the Swedish Association of Otolaryngology, 2018, see attached poster and abstract pdf.

The information in this press release is information that Enzymatica is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 8:45 a.m. on April 11, 2018.

For more information, please contact:

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a Swedish life science company that develops and sells medical devices for infection-related diseases. The products are based on a barrier technology that includes marine enzymes. The company’s first product is ColdZyme® Mouth Spray, which can prevent colds and reduce the duration of disease. The product has been launched in about ten markets. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company has its headquarters in Lund and is listed on Nasdaq First North. For more information, visit:www.enzymatica.com.

Enzymatica’s certified advisor is Erik Penser Bank.

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New ColdZyme study in elite athletes confirms preventive effect and reduced duration of illness

News   •   Apr 09, 2018 09:30 GMT

New customer survey – ColdZyme prevents colds and reduces severity and duration among cold sufferers

News   •   Dec 27, 2017 07:45 GMT

In a recent consumer survey conducted by GfK, over 40% of customers state that they use ColdZyme preventively and if they nevertheless do catch a cold, almost 80 percent state that symptoms are milder and of shorter duration.

In November GfK conducted a consumer survey on behalf of Enzymatica to study how ColdZyme customers perceive ColdZyme’s advantages and to assess the market in general. The survey included 100 customers in the common-cold category and 100 ColdZyme users in Sweden. The findings confirmed that most ColdZyme users either take ColdZyme preventively, or for early symptoms such as sore throat or malaise. The most common reasons that consumers chose to use ColdZyme was either the beneficial effect of the product, or based on the recommendation of a pharmacist, colleague or friend. 42% of ColdZyme users state that they use ColdZyme preventively and if they catch a cold nevertheless, 79 percent state that the cold symptoms were milder or of shorter duration.

“ColdZyme users’ perceptions as reported in GfK’s survey are well in line with what we have seen in previous clinical studies, such as COLDPREV, and our observation studies among athletes and among personnel at preschools and senior housing facilities,” says Fredrik Lindberg, CEO of Enzymatica.

In general, ColdZyme users thought that the product was well tolerated and effective. The Swedish pharmacy market has about 170 products in its cold category and both ColdZyme products (7 and 20 ml) are on the top ten list. As a brand, ColdZyme is established on the top five list of best-sellers in value.

For more information, please contact:
Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB
Enzymatica AB is a Swedish life science company that develops and sells medical devices for infection-related diseases. The products are based on a barrier technology that includes marine enzymes. The company’s first product is ColdZyme® Mouth Spray, which can prevent colds and reduce the duration of disease. The product has been launched in about ten markets. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company has its headquarters in Lund and is listed on Nasdaq First North. For more information, visit:www.enzymatica.se.

Enzymatica’s certified advisor is Erik Penser Bank.

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Enzymatica announces a study showing the ability of ColdZyme to deactivate major common cold viruses

Press Releases   •   Nov 14, 2017 12:22 GMT

Enzymatica announced today a publication in a peer-reviewed journal presenting the results of an in vitro study showing the ability of ColdZyme® Mouth Spray to deactivate the majority of viruses that cause the common cold. The study demonstrated that ColdZyme deactivated the viruses tested and prevented viral-induced cytopathic effect by 64.5 % to 99.9 %. These results indicate that ColdZyme might have clinical benefits in prevention and treatment of the common cold.

The medical device ColdZyme is a mouth spray that forms a barrier in the throat against common cold viruses. The barrier solution of the device is composed of glycerol and Atlantic cod trypsin. The study was conducted by an independent, accredited and certified laboratory. The goal of the study was to determine the ability of ColdZyme to deactivate several viruses known to cause the common cold in humans. A virucidal efficacy suspension test was conducted using ColdZyme against viruses belonging to the four virus families known to cause the majority of common colds[1]. ColdZyme deactivated rhinovirus type 1A by 91.7 %, rhinovirus type 42 by 92.8 %, human influenza A virus H3N2 by 96.9 %, respiratory syncytial virus (RSV) by 99.9 % and adenovirus type 2 by 64.5 %. Furthermore, cytotoxicity was not detected at any dilution or cell line tested.

“The results indicate that ColdZyme can offer a protective barrier against most common cold viruses, known to cause the disease. This is also supported by our previous clinical study, COLDPREV[2], and our open label studies,” says Fredrik Lindberg, CEO of Enzymatica.

The in vitro study was based on a standardised and validated methodology adapted to mimic the environment in vivo in the oropharynx (mouth and throat) where viruses take hold, invade and cause the disease.

The basis for the use of ColdZyme against the common cold is thought to partly depend on the ability of trypsin in cleaving proteins on the surface of viruses important for infection. This will inhibit viruses in binding to cellular receptors, thereby preventing or stopping the proliferation of an infection.

The information in this press release is information that Enzymatica is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out below, at 13:00 CET on November 14, 2017

For more information, please contact:

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a life science company that develops and sells medical devices for infection-related diseases. The products are based on a barrier technology that includes marine enzymes. The Company’s first product is ColdZyme® Mouth Spray, which can prevent colds and reduce the duration of disease. The product has been launched in around ten markets. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company is headquartered in Lund and is listed on Nasdaq First North. For more information please visit:www.enzymatica.se.

Enzymatica’s Certified Adviser is Erik Penser Bank.

[1]Stefansson, B., Gudmundsdottir, Á. and Clarsund, M. (2017). A medical device forming a protective barrier that deactivates four major common cold viruses. Virology: Research & Reviews, 1 (5). doi:10.15761/VRR.1000130

[2] COLDPREV: https://doi.org/10.4236/ojrd.2017.74013

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ColdZyme study – Most recommended cold product at pharmacies

News   •   Nov 09, 2017 08:00 GMT

A new market survey shows that ColdZyme® Mouth Spray is the cold product that pharmacy staff in Sweden recommend most[1]. The majority of consumers who asked for help and recommendations at the pharmacy regarding colds were advised to use ColdZyme. In addition, recent statistics from Nielsen Data show that ColdZyme is the most successful brand launch of a new cold product[2] in over 30 years. The product has achieved a market share of 5 % (value) in the cold category since its launch in Sweden in 2013.

Market research company GfK was commissioned by Enzymatica to conduct a market survey at

93 pharmacies in the Stockholm, Gothenburg and Skåne metropolitan areas. “Mystery shoppers” who pretended to be consumers with symptoms that included feeling sick and a sore throat asked pharmacy staff to recommend something that could help with a cold. ColdZyme was the product recommended more often than other cold products to prevent and shorten the duration of a cold. ColdZyme was recommended by 67 percent of pharmacy staff, while only 26 percent recommended the product that received the second highest number of votes. The results are statistically significant.

  • Spraying in the mouth and throat causes a protective barrier to form on the mucosa. The barrier captures the cold virus and deactivates the ability of the virus to infect cells, which protects the throat and allows the body to rid itself of the virus naturally,” says Fredrik Lindberg, CEO of Enzymatica.

Typical occasions when the risk of being infected with colds increases include large family gatherings, train and air travel, at work in an open office landscape, or during typical cold periods such as the end of vacation, the start of school or the winter holiday season.

  • Using the spray for prevention when you are exposed to an increased risk of contamination makes it possible to prevent a cold from breaking out. And if you’ve already caught a cold, the duration of disease can be reduced by using ColdZyme,” says Fredrik Lindberg.

Of the 5 best-selling brands within colds, ColdZyme is the only completely new brand to be launched in over 30 years. ColdZyme currently has a market share of 5 % (value), and is also the 5th best-selling brand in Sweden that is sold in the cold category in Swedish pharmacies (Nielsen Data, 20170930).

Enzymatica has conducted a number of user studies, including studies in which elite athletes and preschool and elder care staff have used ColdZyme. The results show findings such as a significant reduction in the number of sickness absence days and milder cold symptoms when participants in the studies did catch colds.

For more information, please contact:

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a Swedish life science company that develops and sells medical devices for infection-related diseases. The products are based on a barrier technology that includes marine enzymes. The company’s first product is ColdZyme® Mouth Spray, which can prevent colds and reduce the duration of disease. The product has been launched in about ten markets. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company has its headquarters in Lund and is listed on Nasdaq First North. For more information, visit:www.enzymatica.se.

Enzymatica’s certified adviser is Erik Penser Bank.

About Mystery Shopping

The © GfK Mystery Shopping and Attitudinal Study was conducted in April and May 2017. A total of 93 pharmacies were visited in the Stockholm, Gothenburg and Skåne metropolitan areas. The mystery shopper presented with symptoms such as feeling sick and/or a sore throat and asked for a product that could help. Mystery Shopping conducted by GfK shows that ColdZyme is recommended by pharmacists significantly (P <0.001) more often than other cold products to prevent or reduce the duration of a cold.

[1] © GfK Mystery Shopping and Attitudinal Study | May 2017

[2] Nielsen Data, 12M MAT, 20170930

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Complete article from COLDPREV I study published – strengthens documentation for ColdZyme

News   •   Oct 18, 2017 09:00 GMT

ColdZyme cold spray reduces sickness absence among preschool staff

News   •   Oct 17, 2017 07:00 GMT

Enzymatica has evaluated ColdZyme® Mouth Spray against common cold, for colds among preschool staff during the cold season. The results show that the use of ColdZyme reduced sickness absence by more than three days, from 7.4 to 4.1 days. In cases where the staff in the study did catch a cold, the symptoms of infection were less severe.

Enzymatica conducted an observation study with 15 subjects whom used ColdZyme to prevent colds during “the common cold season” (October-March). The 15 subjects, whom work at a preschool centre, all completed the study. Participants were instructed to use ColdZyme as soon as they were exposed to colds, and to use ColdZyme at the first sign of cold symptoms and to continue until the symptoms disappeared. Sickness absence records, for the control period during the previous winter, were available for the participants.

The purpose of the study was to evaluate whether ColdZyme can be used to prevent colds or to reduce the duration and severity of colds among preschool staff, thereby reducing socio-economic costs. Conditions at preschool centres are conducive to the spread of infections. An infected child can easily infect the staff, resulting in reduced work capacity and sickness absence.

The study results show that when taken preventively and at the first signs of cold symptoms, ColdZyme reduced short-term sick leave among personnel from 7.4 to 4.1 days during a six-month period compared with the control period. As a result, average sickness absence decreased by 3.3 days. In addition, study participants reported that they had not noticed any side effects when using ColdZyme.

  • “We have previously conducted similar studies for other groups such as elderly care home staff and elite athletes. Just as in these studies, our latest evaluation of preschool staff shows that ColdZyme is an effective way to reduce both duration of illness and the severity of colds” says Fredrik Lindberg, CEO of Enzymatica.

A previous study[1]in Sweden has shown that the total cost and productivity loss due to sick leave because of colds and allergies (rhinitis) is 5.1 days, or just over SEK 5,000 per person per year. Reducing sick leave by one day per person per year could entail savings of over SEK 4 billion.

The current study among preschool staff supports the findings from a previous cold study – COLDPREV[2] – that ColdZyme reduces the quantity of virus by up to 99% and can reduce the number of sick days by more than half.

Link to preschool study: https://doi.org/10.4236/ojrd.2017.74014

For more information, please contact:

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a life science company that develops and sells medical devices against infectious diseases. The products are based on a barrier technology, which includes marine enzymes. The company’s first product is ColdZyme® Mouth Spray that can prevent cold, and can shorten the disease period. The product has been launched in about ten markets. The strategy is to continue to grow by strengthening its position in existing markets and expanding to more geographic markets through established partners. The company is headquartered in Lund and is listed on Nasdaq First North. For more information, visit: www.enzymatica.com

  • [1]Hellgren, J., Cervin, A., Nordling, S., Bergman, A., and Cardell, L. O. (2010) Allergic rhinitis and the common cold–high cost to society. Allergy 65.6, 776-783. https://doi.org/10.1111/j.1398-9995.2009.02269.x
  • [2]Clarsund et al, Common cold prophylaxis using ColdZyme Mouth Spray, Congress of the Nordic Association of Otolaryngology Copenhagen

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A study of elite athletes shows that ColdZyme provides protection as evidenced by fewer sick days and lost training days, as well as improved quality of life

News   •   Jun 21, 2017 06:30 GMT

Enzymatica is now publishing the results of a study1 in which Swedish elite athletes used ColdZyme® Mouth Spray to protect against and reduce the symptoms of colds. The results of the study show that ColdZyme reduced the number of sick days by more than 50 percent in the two groups of hockey players and biathlon skiers compared with previous control periods. The study also shows that the elite athletes who came down with colds and who used ColdZyme experienced milder symptoms and improved quality of life compared with untreated common colds.

Enzymatica conducted a study of elite athletes who used ColdZyme for 3-12 months during the winter seasons 2012-2014 in Sweden. In all, 11 biathlon skiers, 29 hockey players and 20 handball players participated and submitted information on number of days absent from training and competition. In addition, those who came down with colds responded to questions about their symptoms and quality of life.

The study results show that the average number of sick days per athlete and month when using ColdZyme significantly declined, by 51 percent for the biathlon skiers and 67 percent for the hockey players, compared with the control periods when ColdZyme was not used. The athletes in the study who became infected reported milder symptoms and significant improvement in quality of life (for example, improved sleep and performance) compared with common cold sufferers not treated with ColdZyme. Nine of 11 biathlon skiers reported that they felt better or much better when using ColdZyme and that they had milder or much milder cold symptoms. The handball players reported similar results, where 76 percent responded that when using ColdZyme the cold was so mild that it had little or no effect on quality of life.

  • “Using ColdZyme has been very important for my training as a biathlon skier. Before I began using ColdZyme I could have 30 to 40 days of sick leave per season, compared with 3-5 days when using ColdZyme,” says Torstein Stenersen, who belongs to the Swedish biathlon team.
  • “The results of this study confirm the results of our first clinical study (COLDPREV I), which among other things showed a 50-percent reduction in number of sick days. This study of elite athletes shows that use of ColdZyme can be a simple and practical way to protect against colds, as evidenced by a reduction in the number of sick days and the quantity of cold symptoms,” says Fredrik Lindberg, CEO of Enzymatica.

1 Clarsund, M. Evaluation of ColdZyme Mouth Spray for the Protection against Common Cold in Elite Athletes to Reduce Unwanted Absence from Training and Competition. Open Journal of Respiratory Diseases, 2017, 7, 103-109. https://doi.org/10.4236/ojrd.2017.73010

For more information please contact:
__________________________________________________________________________________

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB
Enzymatica AB is a life sciences company that develops and sells medical devices for fighting infectious diseases. In a short period of time, the company developed ColdZyme®, a unique mouth spray for fighting colds, launched the product in eight markets and established it as one of the best-selling cold products in Swedish pharmacies measured in SEK. Our strategy is to continue growing by strengthening our position on existing markets and expanding to more geographic markets via established partners. The company’s head office is in Lund and it is listed on the Nasdaq First North. For more information, please go to: www.enzymatica.se.

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Enzymatica receives record order from STADA Arzneimittel AG

Press Releases   •   Jun 14, 2017 09:45 GMT

Enzymatica has received its largest order to date for a total of about SEK 12 million. The global pharmaceutical company STADA Arzneimittel AG (“STADA”), headquartered in Germany, has ordered Enzymatica’s cold product ColdZyme® Mouth spray for the German, Belgian and Austrian markets for the common cold season after the summer.

The order is a result of the cooperation agreement that Enzymatica and STADA reached in February 2017. The agreement grants STADA exclusive rights to sell, market and distribute ColdZyme in Germany, the largest market for OTC products in Europe, as well as in Belgium and Austria.

  • “We are now beginning to see the results of our efforts to sign agreements with international distributors for the major OTC markets. The order is the largest in Enzymatica’s history and is worth much more than the entire sales of SEK 9.6 million for the first quarter this year. The order confirms the commercial potential of ColdZyme and our technology platform,” says Fredrik Lindberg, CEO of Enzymatica.

Enzymatica expects to deliver the order at the end of the summer and the revenue will have an impact on the company’s third quarter sales.

STADA is a publicly-listed German company with a traditionally strong presence in Europe, especially in Germany. STADA is an international company and its five largest markets are Germany, Russia, the UK, Italy and Spain. In 2016 the STADA Group generated sales of EUR 2,139 million and had 10,839 employees all over the world.

The information in this press release is information that Enzymatica is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out below, on June 14, 2017 at 08.00.

For more information please contact:
_______________________________________________________________________

Fredrik Lindberg, CEO, Enzymatica ABTel: +46 (0)708-86 53 70 | Email: fredrik.lindberg@enzymatica.com

About Enzymatica AB

Enzymatica AB is a medical device company that develops and sells medical devices for infection-related diseases. In just a short period of time, the company developed ColdZyme®, a unique mouth spray for colds, launched the product in eight countries and became established among the top-selling cold products (denominated in SEK) at Swedish pharmacies. The strategy is to continue to grow by strengthening the Company’s position in existing markets and expanding into new geographic markets through established partners. The company is headquartered in Lund and is listed on Nasdaq First North. For more information please visit:www.enzymatica.se.

Enzymatica’s Certified Adviser is Erik Penser Bank.

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About Enzymatica AB (publ)

Welcome to Enzymatica AB

Enzymatica is a publicly traded medical device company focused on research, development and sales of innovative enzyme-based products. Enzymaticas products is based primarily on a barrier technology, utlizing a cold adapted enzyme that can be used to create active protective barrier against pathogens. In close collaboration with clinical researchers, the company develops new products for upper respiratory infections, oral infections and inflammations, in dermatology and vetrinary applications.Enzymatica develops products in different market segments to create better customer value , broad recognition and market presence. The sales goes via our own organisation in Scandinavia and through strategic distribution and cooperation agreements for selected geographic markets and countries.