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Enzymatica enters into partnership agreement with STADA Arzneimittel AG

Press Releases   •   Feb 13, 2017 12:15 GMT

The agreement grants STADA exclusive rights to sell, market and distribute Enzymatica’s common cold product ColdZyme® in Germany. STADA is a global pharmaceutical company, headquartered in Germany, with a strong presence in Europe and leading positions in the cough and cold category in Germany, UK, and Russia.

We are very pleased to have signed the agreement with STADA as our marketing, sales, and distribution partner for Germany, particularly since Germany is the single largest market for over-the-counter products in Europe. This agreement confirms the commercial potential for ColdZyme outside of Scandinavia, and endorses the interest in Enzymatica’s technology platform”,says Fredrik Lindberg, CEO of Enzymatica.

"We are very excited about our agreement with Enzymatica to help maximize the ColdZyme opportunity in Germany. ColdZyme’s unique product offering is different to traditional cold therapies and is a perfect fit to our existing portfolio as well as to our strategy of growing our brandedbusiness on the back of launching innovative, new products”, says Wolfram Gollin, Head of Marketing STADA GmbH.

The company’s first product, ColdZyme, is a unique mouth spray for use against the common cold.

In Europe, ColdZyme is directly marketed and sold by Enzymatica in Sweden, Norway and Denmark and sold through marketing and sales partners in Spain, Finland, Iceland and Greece. In the UK, the ColdZyme business is handled by a sales agent.

For more information, please contact:

Fredrik Lindberg, CEO Enzymatica AB Tel: +46 708-86 53 70 | E-post:

This information is information that Enzymatica AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 0830 CET on February 13, 2017.


Enzymatica is a life science company who develops and sells medical device products against infectious-related diseases. Over a short period the company has developed a unique oral spray for colds, ColdZyme®, and launched it on eight markets. The product has become one of the leading articles for colds in Swedish pharmacies. Enzymatica’s strategy is to continue growing by strengthening its position in existing markets and to expand to more geographical markets through well-established partners. The company is headquartered in Lund, Sweden and is listed on Nasdaq First North. For more information, please visit

Enzymaticas Certified Adviser is Erik Penser Bank.

STADA Arzneimittel AG

STADA Arzneimittel AG is a publicly-listed globally leading generics producer with a traditionally strong presence in Europe and especially Germany. STADA is internationally-oriented and the Top 5 markets are Germany, Russia, UK, Italy and Spain. STADA generated Group sales of € 2.115,1 million in 2015 and had 10,532 employees worldwide. STADA has its headquarters in Bad Vilbel, Germany.

For more information visit

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ColdZyme demonstrates reduced sick leave during cold season

News   •   Dec 22, 2016 07:45 GMT

Enzymatica presents results recently published in Open Journal of Respiratory Diseases (OJRD)[1], Enzy-003, an open label evaluation by elderly care personnelatEksjö Municipality, investigating the impact of ColdZyme on sick leave during the cold season. ENZY-003 demonstrated a substantial reduction in individual average sick leave days, reduced from 5.2 to 3.7 days among 74 employees at an elderly care residence using ColdZyme during the cold season, compared to the previous year. In addition, 63 percent of those who caught colds reported that their symptoms were milder while using ColdZyme in comparison to previous colds. This result is encouraging and shows the potential to reduce sick-leave days by using ColdZyme in the workplace.

The Enzy-003 study, carried out at a Swedish elderly care housing at Eksjö Municipality, compared the sick leave frequency among 111 employees during a five-month period of ColdZyme treatment, with that registered during the same period the previous year. 24 subjects were excluded in the analysis due to having long-term sickness, not attributed to the common cold (>29 days’ sick leave in 5 months). A substantial reduction of number of sick-leave days was observed among the remaining 74 subjects, with individual average sick leave days reduced from 5.2 to 3.7 days, (p=0.05)[2] and total sick leave days decreasing from 392 without, to 279 with ColdZyme.According to the study results, 63 percent of the staff reported that their symptoms were milder while using ColdZyme in comparison to previous infections.

“Although upper respiratory tract infections can hardly be considered a severe illness, colds pose a major economic burden for both society and the individual. The health economic consequences are considerable for sickness absences both in elderly care and in other public services,” says Christina Bråkenhielm Persson, Healthcare Director at Eksjö Municipality.

Fredrik Lindberg, CEO of Enzymatica commented:” We are satisfied with the positive outcome of ENZY-003, which is a study that reflects a real life situation during winter season”.

The current study supports the results of a previous cold study – COLDPREV – indicating that ColdZyme can reduce the number of sick days.

ColdZyme, being one of the few treatments that addresses the source of common cold by protecting the throat from virus attachment, has in a few years established itself as one of the best-selling common cold products in Swedish pharmacies.

Today the product is marketed and sold in Sweden, Denmark, Norway, Finland, Iceland, UK and Spain. The company is in negotiations with a number of potential distributor for the launch of ColdZyme in other markets. In the beginning of November Enzymatica signed an exclusive distribution agreement with Endeavour Consumer Health for Australia and New Zealand for marketing and sales of ColdZyme.

[1] Clarsund et al, Evaluation of ColdZyme Mouth Spray against Common Cold in Elderly Care Personnel, Open Journal of Respiratory Diseases, 2017, 7, 12-1

[2] p-value, statistical significance value

For more information, contact

Fredrik Lindberg, CEO, Enzymatica AB Tel: +46 708-86 53 70 | Email:

About Enzymatica AB

Enzymatica AB is a life sciences company that develops and sells medical devices for fighting infectious diseases. In a short period of time, the company developed ColdZyme®, a unique mouth spray for fighting colds, launched the product in seven markets and established it as one of the best-selling cold products in Swedish pharmacies measured in SEK. Our strategy is to continue growing by strengthening our position on existing markets and expanding to more geographic markets via established partners. The company’s head office is in Lund and it is listed on the Nasdaq First North. For more information, please go to:

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Medical case report on promising treatment with ColdZyme® of patients with primary immunodeficiency

News   •   Nov 09, 2016 14:00 GMT

Promising results after using ColdZyme in a patient with primary immunodeficiency has recently been published in the October issue of the Journal of Medical Case Reports. The publication describes Enzymaticas product ColdZyme Mouth spray that was used over a period of 15 months, reducing the incidence of upper respiratory tract infections with a twelve year old patient with primary immunodeficiency. During the treatment with ColdZyme, the patient and parents registered a reduction of cold symptoms and therefore an improved quality of life. Persistent infections of the oral cavity healed for the first time in several years, and the patient’s schooling was almost normalized.

A 12-year-old boy diagnosed with Variable Immunodeficiency (common variable immunodeficiency, CVID) began using ColdZyme three years ago, hoping to prevent contracting the common cold virus. The boy had since the age of two years been treated with weekly infusions of adequate doses of IgG (Immunoglobulin G) at a dose of 100-150 mg/kg/week according to the international and national guidelines. Before treatment with ColdZyme, the patient had recurrent infections of the ears, sinuses, nose, bronchi and lungs - which led to frequent absences from school, hospital stays and reduced quality of life. The boy was in addition to the IgG treatment also treated with antibiotics for bacterial infections, and had on one occasion been on prophylactic antibiotic therapy for several months. In an attempt, hoping to reduce the number of cold episodes, the parents let the boy spray ColdZyme twice daily, morning and evening, while treatment with IgG and antibiotics, if necessary, proceeded as usual. The parents and the boy kept a detailed infection-diary both before and during treatment with ColdZyme.

The result of treatment with ColdZyme showed a substantial reduction both in the number of infections and the symptoms of infection, and reduced absenteeism in school, from 1.4 days per week to 0.3 days per week, during the 15-month treatment period, compared to a 21 months period before without treatment.

  • Patients with primary immunodeficiency suffer from many infections before they get treatment with IgG.This treatment is to the vast majority of patients very effective, but there is a smaller group of patients, that despite adequate IgG treatment continues to have an increased frequency of infections in the respiratory tract. The effect of ColdZyme with this patient is very interesting and follow-up studies in a larger group of people with primary immunodeficiency will be very interesting to take part of, says Ann Gardulf, R.N., PhD, Associate Professor at Karolinska Institutet in Stockholm.
  • When ColdZyme was used in order to reduce the number of common cold episodes, it seems that the spray also had effect on other secondary upper respiratory infections in the oral cavity and pharynx. We now proceed to evaluate the possibility of larger studies. The unexpectedly positive results have also prompted us to apply for a patent for the use of ColdZyme at immunodeficiency, says Mats Clarsund, Research Director at Enzymatica.

In Sweden, The National Board of Health and Welfare and the Healthcare anticipate that there are approximately 600 patients diagnosed with variable immunodeficiency. In total there are thousands of children and adults with some form of primary immunodeficiency. Children and adults with primary immune deficiency usually need life-long treatment with IgG. Preparations of concentrate of IgG are extracted from the plasma of healthy donors. Despite adequate IgG therapy, some patients continue to have upper respiratory infections, which make it interesting to find complementary treatments.

For more information, contact:

Fredrik Lindberg, CEO Enzymatica AB Tel: 0708-86 53 70 |

About ColdZyme

Colds are caused by viruses. ColdZyme is unique because it fights the cause of the cold, the cold virus, instead of treating the symptoms once the patient has already gotten sick like many other products. ColdZyme can thus both prevent and shorten colds.

About Enzymatica AB

Enzymatica AB is a life sciences company that develops and sells medical devices for fighting infectious diseases. In a short period of time, the company developed ColdZyme®, a unique mouth spray for fighting colds, launched the product in six markets and established it as one of the best-selling cold products in Swedish pharmacies measured in SEK. Our strategy is to continue growing by strengthening our position on existing markets and expanding to more geographic markets via established partners. The company’s head office is in Lund and it is listed on the Nasdaq First North. For more information, please go

Enzymaticas Certified Advisor is Erik Penser Bank.

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Customer studies: ColdZyme users fight colds early and actively

News   •   Apr 27, 2016 12:15 GMT

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Information about Enzymatica’s new rights issue

News   •   Apr 20, 2016 13:05 GMT

Today Enzymatica has published the prospectus for the new rights issue with pre-emptive rights for the company’s shareholders. To read more about the subscription of shares – see under “Investors” and “New rights issue April 2016” at the company’s web site. Here you will find a brief description of the rights issue (short version of the prospectus) and how one subscribes for shares and application form. The entire prospectus in Swedish is also available.

For more information, please contact:

Carl-Johan Wachtmeister, deputy communication officer Enzymatica

Tel: 0701-88 50 21 | E-post:

Important information

The information in this News does not contain or constitute an offer to acquire, subscribe or otherwise trade in shares, subscription rights or other securities in Enzymatica AB (publ). Any invitation to the persons concerned to subscribe for shares in Enzymatica AB (publ) will only be made through the prospectus that Enzymatica AB (publ) estimates to publish on or about 20 April 2016.

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Frequently asked questions and answers about Enzymatica's acquisition of Zymetech

News   •   Jan 28, 2016 07:24 GMT

Why is Enzymatica purchasing Icelandic company Zymetech?

The acquisition of Zymetech aims to accelerate our expansion and reduce the company’s risks of competition. It makes Enzymatica a stronger and more attractive partner in the context of businessand on the capital market.

How does Enzymatica benefit from the acquisition of Zymetech?

The acquisition will give Enzymatica control over the entire production chain, we will own patent protection for our products on several key markets and we will substantially reduce the risk of competition by acquiring global exclusive rights to the deep-sea enzyme. In addition, Zymetech brings expertise in enzyme and formulation technology to the table, which is conducive to the development of new products. When combined with the other improvements we have made to the company over the past year, such as in terms of quality and regulations, this gives us the solid foundation required to make our planned geographic expansion a reality.

What are the details of the transaction?

Enzymatica AB (publ) (”Enzymatica”) has signed an agreement to acquire the shares of Zymetech ehf. The purchase price consists of 20,9 million new shares and 4 million new warrants in Enzymatica, and the acquisition is thus planned to be completed via a non-cash issue of shares in Enzymatica offered to Zymetech’s shareholders. The transaction is subject to approval at an extraordinary general meeting Enzymatica will give notice of.

What does the transaction entail with respect to your patent protection for ColdZyme?

The patent prevents others from developing or selling products based on the enzyme from cod and expires at the end of 2020, i.e. in five years. The patent covers Europe and certain key markets outside of the EU, including the largest markets for OTC products – Oceania, Canada, Russia, Poland, China, India and Mexico.

What is your opinion on the fact that the patent does not cover the US and Japan, the largest markets for medical equipment/OTC products?

Given that Zymetech is the only producer of the relevant deep-sea enzymes, the merger also gives Enzymatica global control over the raw material, which substantially slows down competition in important countries where Enzymatica does not have full patent protection, such as the US. Enzymatica has a technological lead of several years across the globe. In October 2015, a new patent application was published for a recombinant trypsin, which we expect will supplement the patent for the natural trypsin when it expires. This patent will cover the US as well. We have also filed several patent applications to protect our technology.

What role will Zymetech have in Enzymatica?

Researchers and product developers from Zymetech will be added to the research and development department while continuing to work in Iceland. All production and refinement of the enzyme raw material will also remain in Iceland, as well as several other functions. Zymetech's founder will become the largest single shareholder of Enzymatica and will initially be offered two board posts and a position on the nominations committee.

Does Zymetech have any agreements with distributors on the international market for sales of trypsin and for their own spray?

Zymetech mainly has agreements for dermatology products in Germany, the UK and an Asian market.

How much sales do these agreements generate for Zymetech?

SEK 3-5 million per year.

Why does Enzymatica want to conduct a preemptive rights issue of SEK 60 million?

The capital contributed from the issue will bolster the company’s financial position and we believe that this will enable faster geographic expansion. The purpose is to enable us to pursue commercial opportunities more aggressively and thus foster a long-term increase in the sales of cold product ColdZyme.

The capital contribution will facilitate preparation for the regulatory approval in the US, Asia, Australia and other regions outside of Europe, continuing diversification of the product portfolio and solid sales support for distribution partners in the form of a small internal marketing structure, including key personnel such as international product managers.

What does it mean that the new share issue has preemptive rights for existing shareholders?

It means that those who are registered as shareholders on the record date will receive warrants in proportion to their shareholdings. These shareholders are then given the opportunity to subscribe for new shares before others. The preemptive rights are represented by the warrants allotted.

Why is Enzymatica requesting a mandate to be able to conduct a private placement of SEK 40 million?

The reason for the extended mandate for a private placement is to take advantage of future opportunities to bring in strong long-term owners and provide additional financing for the company's growth strategy.

You raised SEK 80 million just over two years ago, how have these funds been used?

We launched ColdZyme on five new markets: Norway, Denmark, the UK, Finland and Spain in January 2016. As part of these product launch efforts, we ensured that the product is in compliance with each country's legal and regulatory requirements, e.g. by supplementing the documentation forming the basis for the product’s registration and making adaptations to advertising and marketing materials. Intensified quality efforts within the company have been underway since one year ago. These efforts are necessary to reach more geographic markets. We have also expanded our organizational structure so it can cope with the expansion, doubling our workforce to 15 one year ago. In addition, we have continued to invest in production and development projects related to ColdZyme.

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Questions and Answers – regarding the ASA decision, for marketing- and web material of ColdZyme in the UK

News   •   Jan 27, 2016 15:51 GMT

1.Why has the ASA ruled on the content of your ColdZyme ads and Boots’ website? 

ASA is acting on two complaints about claims we have made in a poster and that were made about the product on Boots’ website back in 2014, we have already taken the appropriate corrective action, changing the claims. ASA has the responsibility to see that advertising rules in the CAP code (The UK Code of Non-broadcast Advertising, Sales Promotion and Direct Marketing) in UK are followed and therefore looked into these complaints.

2.What scientific data do you have to support the claims in the ads?

We have one placebo-controlled study and a few open label studies. These studies support the following claims; ColdZyme can reduce the viral load and can help reduce the number of sick-days suffered with a common cold, when used prophylactically.We feel that these are reasonable claims, and these have been adjusted to comply with the ASA decision.

3.You state in the ads “could prevent or shorten the common cold at the first signs” – what data do you have to support this statement?

Following the ASA decision we have already adjusted our claim in web and marketing material to adhere to the decision. ColdZyme is unique since it acts on the cold virus itself, as opposed to addressing symptoms when already ill. ColdZyme can reduce the viral load in the throat and can help reduce the number of sick-days of a common cold, when used prophylactically.

4.Do you intend to follow and comply with the ASA decision? And if yes, in what way?

We have considered the ASA decision, and have already taken the appropriate corrective action. The poster is not in use, and the website has been amended accordingly.

5.Don’t you think that this type of marketing and information will be harmful to the trust of your product and company?

We strongly believe that our current marketing is supported by reliable and relevant clinical data. Bear in mind that we also have an obligation to our customers to guide them in how to use ColdZyme in the best way. According to good clinical and marketing practice, we are constantly increasing our knowledge around the product by collecting more clinical data as well as post-marketing information for the benefit of the user.

6.How have you communicated with Boots and Lloyds?

The ASA decision has been shared with Boots and Lloyds and corrective action has been taken to adhere to ASA’s decision.

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Fredrik Lindberg appointed CEO of Enzymatica

Press Releases   •   Nov 17, 2014 10:00 GMT

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Launch in Denmark expands ColdZyme® to all of Scandinavia

Press Releases   •   Oct 13, 2014 06:30 GMT

Enzymatica, which develops and sells medical device products based on an enzyme from deep-sea cod, has signed agreements with the pharmacy chain Pharma+ and the wellness chain Matas in Denmark to sell ColdZyme® against common colds. From November this year, ColdZyme will be available on the Danish market, and thus in all of Scandinavia.

"According to plan, we are expanding to our neighboring countries using our own sales organization, building a platform of close relationships with the pharmacy and wellness market throughout Scandinavia. The expanded geographic presence sets the scene for continued growth and further geographic expansion. A strong domestic market position supports successful international distribution later on", says Christian W. Jansson, CEO, Enzymatica.

ColdZyme will be sold in Denmark through Pharma+, one of the dominant chains with pharmacies in metropolitan areas, as well as through the wellness chain Matas’ approximately 300 stores throughout Denmark. In a similar way as in Sweden and Norway, the pharmacies will be trained and supported by Enzymatica’s own local sales organization. The product launch will begin in late October and continue throughout the cold season. Enzymatica will conduct a widespread launch campaign to achieve maximum coverage to the Danish population.

"I am delighted that we have ColdZyme in the Danish pharmaceutical market. The product brings something really new in the cold segment by acting directly on the cause of the common cold”, said Jorgen Moestrup, Chairman of Pharma+.

The common cold is one of the most common infectious diseases. Enzymatica estimates that the total value of the non-prescription cold and flu market in Denmark amounts to approximately SEK 375 million.

For more information, please contact:
Christian W Jansson, CEO Enzymatica AB
Phone: +46 706 37 12 58. Email:

Tina Dackemark Lawesson, Senior Communications Officer Enzymatica AB
Phone: +46 46 286 31 00. Email:

About ColdZyme 

ColdZyme ® Mouth spray reduces the risk of getting a cold or shortens the period of illness in the early stages of a cold infection if you are already affected. ColdZyme exerts its effect by creating a protective barrier enzyme in the lining of the mouth and throat. The barrier reduces the viruses' ability to attach to cells in the oral mucosa and cause disease. The product has been on sale via pharmacies and health specialist stores in Sweden since 2013. In 2014 the product expanded to pharmacies in Norway and the Boots pharmacy chain in the UK. For more information, please visit

About Enzymatica AB (publ)

Enzymatica AB (publ) develops and sells medical technology products based on an enzyme from deep-sea cod. They include medical devices for upper respiratory infections and oral health, and veterinary products in oral health and dermatology. The medical portfolio includes ColdZyme® against common colds. The company is headquartered in Lund, Sweden, and is listed on Aktietorget. For more information, please visit

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Enzymatica receives first order for veterinary products from its partner in North America

Press Releases   •   Sep 26, 2014 06:30 GMT

Enzymatica, which develops and sells medical products based on an enzyme from deep-sea cod, is announcing today that its partner Adartis Animal Health has placed a first order for the veterinary products launched in the United States and Canada in July. The order includes KalvatinTM products to a value of about SEK 3 million and is expected to cover market needs for the next six to twelve months. The first part delivery will be made in the fourth quarter of 2014 and is expected to have a positive impact on earnings of more than SEK 1 million.

“Our partner has recently started the work of introduction and the market is in the build-up phase. We look forward to following the activities in the market during the coming fall and winter. Veterinary products broaden our product portfolio and provide a long term opportunity to grow in a new segment,” says Christian W. Jansson, acting CEO of Enzymatica.

The KalvatinTM products are marketed and sold in North America by Enzymatica’s partner Adartis Animal Health. The products target companion animal veterinary clinics. In the United States and Canada, there are about 44,000 veterinary clinics.*

Kalvatin Dermal and Kalvatin Dental are enzyme-based products for treating skin and gum infections, primarily in dogs and cats. The spray/gel creates a protective surface barrier that prevents bacteria from causing infection. Development has been on the same technology platform as Enzymatica’s common cold product ColdZyme®.

The Kalvatin products were launched at the AVMA Annual Convention in Denver, USA on July 25-29, 2014.

For more information, please contact:
Christian W Jansson, acting CEO Enzymatica AB
Phone: +46 706 37 12 58. E-mail:

Tina Dackemark Lawesson, Senior Communications Officer Enzymatica AB
Phone: +46 46 286 31 00. E-mail:

For more information about Adartis and the KalvatinTM products, please visit:

* American Pet Products Associations website 2014.

About Enzymatica AB (publ)

Enzymatica AB (publ) develops and sells medical technology products based on an enzyme from deep-sea cod. They include medical devices for upper respiratory infections and oral health, and veterinary products in oral health and dermatology. The medical portfolio includes ColdZyme® against common colds. The company is headquartered in Lund, Sweden, and is listed on Aktietorget. For more information, please visit

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Contacts 2 contacts

  • Press Contact
  • Senior Communication Officer
  • Corporate Communications
  • gbdmsewoecjozergvqen.rexo@enmuzywxmaygastiyzca.czgom
  • +46(0) 708 19 22 82
  • +46 46 286 31 00

  • Press Contact
  • EVP Marketing & Operations
  • xlulf.blombt@emxhgnzymhuaticjlnia.kziose
  • 0703777328
  • 0462863100

About Enzymatica AB (publ)

Welcome to Enzymatica AB

Enzymatica is a publicly traded biotechnology company focused on research, development and sales of innovative enzyme-based products. Enzymaticas products is based primarily on a cold adapted enzyme that can be used to create active protective barrier against pathogens. In close collaboration with clinical researchers, the company develops new products for upper respiratory infections, oral infections and inflammations, in dermatology and vetrinary applications.Enzymatica develops products in different market segments to create better customer value , broad recognition and market presence. The sales goes via our own organisation in Scandinavia and through strategic distribution and cooperation agreements for selected geographic markets and countries.